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dc.contributor.author
 hal.structure.identifier
PU, Yubing
116261 Institut Charles Delaunay [ICD]
dc.contributor.author
 hal.structure.identifier
MARKS, Robert
300759 Ben-Gurion University of the Negev [BGU]
dc.contributor.author
 hal.structure.identifier
IONESCU, Rodica Elena
116261 Institut Charles Delaunay [ICD]
dc.contributor.author
 hal.structure.identifier
LARATTE, Bertrand
164351 Institut de Mécanique et d'Ingénierie de Bordeaux [I2M]
dc.date.accessioned2017
dc.date.available2017
dc.date.issued2017
dc.date.submitted2017
dc.identifier.issn2352-4928
dc.identifier.urihttp://hdl.handle.net/10985/11618
dc.description.abstractThere is a need by the European Commission (EC) regulations, as well as others, to reduce the in vivo toxicity tests made on animals. Conventional in vitro tests were designed for non-nanoparticle sized entities, and therefore do not necessarily assess the adverse impacts of engineered nanoparticles (ENPs) on humans. Life cycle assessment (LCA) is a widely used methodology for evaluating the environmental performance of products. Nevertheless, the application of LCA on ENPs is difficult because the characterization factors (CFs) of ENPs, as significant input parameters in LCA, remain a major unknown. It is a premise of this study to monitor the chemiluminescence (CL) spectra resulting from the reactive oxygen species (ROS) trigger made from the presence of copper nanoparticles (CuNPs) to porcine neutrophils in vitro, thereby enabling to calculate the porcine and human toxicity CFs. The framework of a scientific consensus model, USEtox model, is selected and the midpoint of CF is set as the inflammation of pig or human. Finally, the present study recommends human and porcine inflammation CFs of CuNPs in Europe to be 1.07 and 2.90 CTU (comparative toxic units) respectively.
dc.description.sponsorshipChina Scholarship Council (CSC)
dc.language.isoen
dc.publisherElsevier
dc.rightsPost-print
dc.subjectCopper nanoparticles
dc.subjectPorcine neutrophils
dc.subjectin vitro chemiluminescence
dc.subjectUSEtox model
dc.subjectCharacterization factor
dc.titleImpact of copper nanoparticles on porcine neutrophils: ultrasensitive characterization factor combining chemiluminescence information and USEtox assessment model
ensam.embargo.terms2017-10-01
dc.identifier.doi10.1016/j.mtcomm.2017.02.008
dc.typdocArticle dans une revue avec comité de lecture
dc.localisationCentre de Bordeaux-Talence
dc.subject.halSciences de l'environnement: Ingénierie de l'environnement
dc.subject.halSciences de l'ingénieur: Micro et nanotechnologies/Microélectronique
ensam.audienceInternationale
ensam.page68-75
ensam.journalMaterials Today Communications
ensam.volume11
ensam.peerReviewingOui
hal.identifierhal-01489194
hal.version1
hal.statusaccept


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