Impact of copper nanoparticles on porcine neutrophils: ultrasensitive characterization factor combining chemiluminescence information and USEtox assessment model
dc.contributor.author
hal.structure.identifier | PU, Yubing
|
dc.contributor.author
hal.structure.identifier | MARKS, Robert
|
dc.contributor.author
hal.structure.identifier | IONESCU, Rodica Elena
|
dc.contributor.author
hal.structure.identifier | LARATTE, Bertrand
|
dc.date.accessioned | 2017 |
dc.date.available | 2017 |
dc.date.issued | 2017 |
dc.date.submitted | 2017 |
dc.identifier.issn | 2352-4928 |
dc.identifier.uri | http://hdl.handle.net/10985/11618 |
dc.description.abstract | There is a need by the European Commission (EC) regulations, as well as others, to reduce the in vivo toxicity tests made on animals. Conventional in vitro tests were designed for non-nanoparticle sized entities, and therefore do not necessarily assess the adverse impacts of engineered nanoparticles (ENPs) on humans. Life cycle assessment (LCA) is a widely used methodology for evaluating the environmental performance of products. Nevertheless, the application of LCA on ENPs is difficult because the characterization factors (CFs) of ENPs, as significant input parameters in LCA, remain a major unknown. It is a premise of this study to monitor the chemiluminescence (CL) spectra resulting from the reactive oxygen species (ROS) trigger made from the presence of copper nanoparticles (CuNPs) to porcine neutrophils in vitro, thereby enabling to calculate the porcine and human toxicity CFs. The framework of a scientific consensus model, USEtox model, is selected and the midpoint of CF is set as the inflammation of pig or human. Finally, the present study recommends human and porcine inflammation CFs of CuNPs in Europe to be 1.07 and 2.90 CTU (comparative toxic units) respectively. |
dc.description.sponsorship | China Scholarship Council (CSC) |
dc.language.iso | en |
dc.publisher | Elsevier |
dc.rights | Post-print |
dc.subject | Copper nanoparticles |
dc.subject | Porcine neutrophils |
dc.subject | in vitro chemiluminescence |
dc.subject | USEtox model |
dc.subject | Characterization factor |
dc.title | Impact of copper nanoparticles on porcine neutrophils: ultrasensitive characterization factor combining chemiluminescence information and USEtox assessment model |
ensam.embargo.terms | 2017-10-01 |
dc.identifier.doi | 10.1016/j.mtcomm.2017.02.008 |
dc.typdoc | Article dans une revue avec comité de lecture |
dc.localisation | Centre de Bordeaux-Talence |
dc.subject.hal | Sciences de l'environnement: Ingénierie de l'environnement |
dc.subject.hal | Sciences de l'ingénieur: Micro et nanotechnologies/Microélectronique |
ensam.audience | Internationale |
ensam.page | 68-75 |
ensam.journal | Materials Today Communications |
ensam.volume | 11 |
ensam.peerReviewing | Oui |
hal.identifier | hal-01489194 |
hal.version | 1 |
hal.status | accept |