Reaction–Diffusion Finite Element Model of Lateral Line Primordium Migration to Explore Cell Leadership
Article dans une revue avec comité de lecture
Date
2014Journal
Bulletin of Mathematical BiologyAbstract
Collective cell migration plays a fundamental role in many biological phenomena such as immune response, embryogenesis and tumorigenesis. In the present work, we propose a reaction–diffusion finite element model of the lateral line primordium migration in zebrafish. The population is modelled as a continuum with embedded discrete motile cells, which are assumed to be viscoelastic and able to undergo large deformations. The Wnt/ß-catenin–FGF and cxcr4b–cxcr7b signalling pathways inside the cohort regulating the migration are described through coupled reaction–diffusion equations. The coupling between mechanics and the molecular scenario occurs in two ways. Firstly, the intensity of the protrusion–contraction movement of the cells depends on the cxcr4b concentration. Secondly, the intra-synchronization between the active deformations and the adhesion forces inside each cell is triggered by the cxcr4b–cxcr7b polarity. This influences the inter-synchronization between the cells and results in two main modes of migration: uncoordinated and coordinated. The main objectives of the work were (i) to validate our assumptions with respect to the experimental observations and (ii) to decipher the mechanical conditions leading to efficient migration of the primordium. To achieve the second goal, we will specifically focus on the role of the leader cells and their position inside the population.
Files in this item
Related items
Showing items related by title, author, creator and subject.
-
Article dans une revue avec comité de lectureAUBRY, Denis; GUPTA, M.; LADOUX, B.; ALLENA, Rachele (Institute of Physics: Hybrid Open Access, 2015)Cell migration, a fundamental mechanobiological process, is highly sensitive to the biochemical and mechanical properties of the environment. Efficient cell migration is ensured by the intrinsic polarity of the cell, which ...
-
Article dans une revue avec comité de lectureBENDAYA, Samy; LAZENNEC, Jean-Yves; ANGLIN, Carolyn; ALLENA, Rachele; SELLAM, N.; THOUMIE, P.; SKALLI, Wafa (Elsevier, 2015)Osteoarthritis is a debilitating disease, for which the development path is unknown. Hip, pelvis and femoral morphological and positional parameters relate either to individual differences or to changes in the disease ...
-
Article dans une revue avec comité de lectureMONDESERT-DEVERAUX, Solenne; ALLENA, Rachele; AUBRY, Denis (Tech Science Press, 2018)Cell migration is the cornerstone of many biological phenomena such as cancer metastasis, immune response or organogenesis. Adhesion-based motility is the most renown and examined motility mode, but in an adhesion-free ...
-
Article dans une revue avec comité de lectureMARTYNENKO, Oleksander V.; ALLENA, Rachele; ZOLOCHEVSKY, O. O. (V. N. Karazin Kharkiv National University, 2017)The review involves clinical and experimental data, constitutive modeling, and computational investigations towards an understanding on how mechanical cyclic loads for long periods of time affect damage evolution in a ...
-
Article dans une revue avec comité de lectureALLENA, Rachele; CLUZEL, Christophe (International Research Center for Mathematics & Mechanics of Complex Systems (M&MoCS),University of L’Aquila in Italy, 2018)Heterogeneous materials such as bone or woven composites show mesostructures whose constitutive elements are all oriented locally in the same direction and channel the stress flow throughout the mechanical structure. The ...