In-vitro cartilage growth: macroscopic mass transport modelling in a three-phase system
dc.contributor.author
hal.structure.identifier | LETELLIER, Samuel
|
dc.contributor.author
hal.structure.identifier | AHMADI-SENICHAULT, Azita
|
dc.contributor.author
hal.structure.identifier | LASSEUX, Didier
|
dc.date.accessioned | 2015 |
dc.date.available | 2015 |
dc.date.issued | 2009 |
dc.date.submitted | 2015 |
dc.identifier.uri | http://hdl.handle.net/10985/9983 |
dc.description.abstract | Transplantation of engineered tissues is of major interest as an alternative to autogenic alogenic or exogenic grafts. In this study, in vitro cartilage cell culture on a fibrous biodegradable polymer scaffold is under concern. The scaffold is first seeded with cells which adhere to the fibres and the system is then grown in a bioreactor. As reported in the literature, hydrodynamics and transport of nutrients and metabolic products during this growth process is of considerable importance, motivating our analysis. A one-equation macroscopic model was first developed in order to describe macroscopic mass transport during in vitro tissue growth using the volume averaging method. This model takes into account a three phase system composed of solid fibres, cell phase and fluid phase and allows determination of the macroscopic quantities as a function of microscopic properties and geometry at any stage of growth. In a second step, numerical tools for the computation of the effective properties were developed and validated. This validation is carried out using results available in the literature for some sub-classes of our model (namely, diffusion, diffusion/reaction and diffusion/advection problems in 2D systems). The behaviour of the macroscopic dispersion tensor for the complete model (diffusion/reaction/advection) in a three phase configuration is studied and the influence of different parameters such as the volume fractions of the phases, Peclet and Kinetic numbers is discussed. |
dc.language.iso | en |
dc.rights | Pre-print |
dc.subject | Tissu growth |
dc.subject | Bioreactor |
dc.subject | Mass transpor |
dc.subject | Modelling |
dc.title | In-vitro cartilage growth: macroscopic mass transport modelling in a three-phase system |
dc.typdoc | Communication sans acte |
dc.localisation | Centre de Bordeaux-Talence |
dc.subject.hal | Sciences de l'ingénieur: Mécanique: Mécanique des fluides |
ensam.conference.title | International Conf. on Challenges of Porous Media |
ensam.conference.date | 2009-03-11 |
ensam.country | Allemagne |
ensam.city | Kaiserslautern |
hal.identifier | hal-01196737 |
hal.version | 1 |
hal.status | accept |