Effect of arteriolar distensibility on the lateral migration of liquid-filled microparticles flowing in a human arteriole
Article dans une revue avec comité de lecture
Date
2021-10-15Journal
Journal of Mechanics in Medicine and BiologyRésumé
A promising advance of bioengineering consists in the development of micro-nanoparticles as drug delivery vehicles injected intravenously or intraarterialy for targeted treatment. Pro cient functioning of drug carries is conditioned by a reliable prediction of pharma- cokinetics in human as well as their dynamical behavior once injected in blood stream. In this study we aim to provide a reliable numerical prediction of dynamical behavior of microparticles in human arteriole focusing on the crucial mechanism of lateral migration. The dynamical response of the microparticle upon blood flow and arteriolar distensibility is investigated by varying main controlling parameters: viscosity ratio, con nement and capillary number. The influence of the hyperelastic arteriolar wall is highlighted through comparison with an in nitely rigid arteriolar wall. The hydrodynamic interaction in a microparticle train is examined. Fluid-structure interaction is solved by the Arbitrary Lagrangian Eulerian method using the COMSOL Multiphysics software.
Fichier(s) constituant cette publication
Cette publication figure dans le(s) laboratoire(s) suivant(s)
Documents liés
Visualiser des documents liés par titre, auteur, créateur et sujet.
-
Article dans une revue avec comité de lectureThe study of artificial microparticles (capsules and vesicles) has gained a growing interest with the emergence of bioengineering. One of their promoting applications is their use as therapeutic vectors for drug delivery, ...
-
Article dans une revue avec comité de lectureA potential flow is presented in this paper for the analysis of the fluid-structure interaction systems including, but not limited to, the idealized human head. The model considers a cerebro-spinal fluid (CSF) medium ...
-
Article dans une revue avec comité de lectureThe ascending branch of the aorta is one of the most stressed organ of the arterial system. We aim to design a biomechanical model for analysing the aorta dynamics under a shock. The model includes the aorta layers and the ...
-
Article dans une revue avec comité de lectureAn analytical and numerical study for the torsional vibrations of viscous fluid-filled three-layer transversely isotropic cylinder is presented in this paper. The equations of motion of solid and fluid are respectively ...
-
Article dans une revue avec comité de lectureThe vibrational characteristics of a microbeam are well known to strongly depend on the fluid in which the beam is immersed. In this paper, we present a detailed theoretical study of the modal analysis of microbeams partially ...