Vertebral strength prediction from Bi-Planar dual energy x-ray absorptiometry under anterior compressive force using a finite element model: An in vitro study
TypeArticles dans des revues avec comité de lecture
Finite element models (FEM) derived from qCT-scans were developed as a clinical tool to evaluate vertebral strength. However, the high dose, time and cost of qCT-scanner are limitations for routine osteoporotic diagnosis. A new approach considers using bi-planar dual energy (BP2E) X-rays absorptiometry to build vertebral FEM using synchronized sagittal and frontal plane radiographs. The purpose of this study was to compare the performance of the areal bone mineral density (aBMD) measured from DXA, qCT-based FEM and BP2E-based FEM in predicting experimental vertebral strength. Twenty eight vertebrae from eleven lumbar spine segments were imaged with qCT, DXA and BP2E X-rays before destructively tested in anterior compression. FEM were built based on qCT and BP2E images for each vertebra. Subject-specific FEM were built based on 1) the BP2E images using 3D reconstruction and volumetric BMD distribution estimation and 2) the qCT scans using slice by slice segmentation and voxel based calibration. Linear regression analysis was performed to find the best predictor for experimental vertebral strength (Fexpe); aBMD, modeled vertebral strength and vertebral stiffness. Areal BMD was moderately correlated with Fexpe (R2 = 0.74). FEM calculations of vertebral strength were highly to strongly correlated with Fexpe (R2 = 0.84, p < 0.001 for BP2E model and R2 = 0.95, p < 0.001 for qCT model). The results of this study suggest that aBMD accounted for only 74% of Fexpe variability while FE models accounted for at least 84%. For anterior compressive loading on isolated vertebral bodies, simplistic loading condition aimed to replicate anterior wedge fractures, both FEM were good predictors of Fexpe. Therefore FEM based on BP2E X-rays absorptiometry could be a good alternative to replace qCT-based models in the prediction of vertebral strength. However future work should investigate the performance of the BP2E-based model in vivo in discriminating patients with and without vertebral fracture in a prospective study.
Files in this item
Showing items related by title, author, creator and subject.
A new method to determine volumetric bone mineral density from bi-planar dual energy radiographs using a finite element model: an ex-vivo study CHOISNE, Julie; TRAVERT, Christophe; VALIADIS, Jean-Marc; KOLTA, Sami; ROUX, Christian; SKALLI, Wafa (French Society of Biomechanics, 2015)Vertebral fractures are one of the most common clinical manifestations with the major adverse consequences of osteoporosis as they usually occur under non-traumatic loading conditions. Height loss, back pain and func-tional ...
A 3D reconstruction method of the body envelope from biplanar X-rays: Evaluation of its accuracy and reliability NÉROT, Agathe; CHOISNE, Julie; AMABILE, Célia; TRAVERT, Christophe; PILLET, Hélène; WANG, Xuguang; SKALLI, Wafa (Elsevier, 2015)The aim of this study was to propose a novel method for reconstructing the external body envelope from the low dose biplanar X-rays of a person. The 3D body envelope was obtained by deforming a template to match the surface ...
VAN DEN ABBEELE, Maxim; VALIADIS, Jean-Marc; LIMA, Lucas; KHALIFE, Pascal; ROUCH, Philippe; SKALLI, Wafa (Columbia University, 2017)Although the use of pedicle screws is considered safe, mechanical issues still often occur. Commonly reported issues are screw loosening, screw bending and screw fracture. The aim of this study was to develop a Finite ...
Lumbar spinal muscles and spinal canal study by MRI three-dimensional reconstruction in adult lumbar spinal stenosis BOISSSIERE, Louis; MOAL, Bertrand; GILLE, Olivier; DE-ROQUEFEUIL, Elise; DURIEUX, Muriel; OBEID, Ibrahim; DOUSSET, Vincent; VITAL, Jean-Marc; SKALLI, Wafa (ELSEVIER, 2017)Background: Lumbar spinal stenosis is degenerative disc disease most common manifestation. If stenosisdegree seems poorly related to symptom severity, lumbar muscles role is recognized. Many studiesreport imaging methods, ...
A new quasi-invariant parameter characterizing the postural alignment of young asymptomatic adults AMABILE, Célia; PILLET, Hélène; LAFAGE, Virginie; BARREY, Cédric; VITAL, Jean-Marc; SKALLI, Wafa (Springer, 2016)Purpose Our study aims to describe the postural alignment of young asymptomatic subjects from head to feet from bi-planar standing full-body X-rays, providing database to compare to aging adults. Novelty resides in the ...