Analyse théorique et expérimentale de la diffusion de la lumière générée par une diode électroluminescente dans des répliques tissulaires

Abstract

The knowledge of the spatial distribution of light within a biological tissue exited by a light source (LASER or LED) is fundamental to achieve optimal photodynamic treatment. In this paper, we develop an analytical model relative to the diffuse fluence rate within a tissue-like medium irradiated by a continuous-wave light emitting diode (LED). The model is based on the two dimensional Fourier transform and applied to a homogeneous tissue slab. The total fluence rate along the axis of the medium was computed by adding the collimated and the diffuse components. The analytical solution was also used to study the depth evolution of the photon fluence rate as functions of the finite source beam size and the tissue optical parameters. Measurement results were performed using a tank filled with a liquid-simulating turbid medium (milk) illuminated with a LED beam. The experimental behaviour results agree with the theoretical predictions.