• français
    • English
    français
  • Login
Help
View Item 
  •   Home
  • Institut de Mécanique et d’Ingénierie de Bordeaux (I2M)
  • View Item
  • Home
  • Institut de Mécanique et d’Ingénierie de Bordeaux (I2M)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Reevaluation of the diametral compression test for tablets using the flattened disc geometry

Article dans une revue avec comité de lecture
Author
MAZEL, Vincent
259761 Université de Bordeaux [UB]
ccGUÉRARD, Sandra
CROQUELOIS, Benjamin
259761 Université de Bordeaux [UB]
ccKOPP, Jean-Benoit
ccGIRARDOT, Jeremie
DIARRA, Harona
259761 Université de Bordeaux [UB]
BUSIGNIES, Virginie
259761 Université de Bordeaux [UB]
TCHORELOFF, Pierre
259761 Université de Bordeaux [UB]

URI
http://hdl.handle.net/10985/11248
DOI
10.1016/j.ijpharm.2016.09.088
Date
2016
Journal
International Journal of Pharmaceutics

Abstract

Mechanical strength is an important critical quality attribute for tablets. It is classically measured, in the pharmaceutical field, using the diametral compression test. Nevertheless, due to small contact area between the tablet and the platens, some authors suggested that during the test, the failure could occur in tension away from the center which would invalidate the test and the calculation of the tensile strength. In this study, the flattened disc geometry was used as an alternative to avoid contact problems. The diametral compression on both flattened and standard geometries was first studied using finite element method (FEM) simulation. It was found that, for the flattened geometry, both maximum tensile strain and stress were located at the center of the tablet, which was not the case for the standard geometry. Experimental observations using digital image correlation (DIC) confirmed the numerical results. The experimental tensile strength obtained using both geometries were compared and it was found that the standard geometry always gave lower tensile strength than the flattened geometry. Finally, high-speed video capture of the test made it possible to detect that for the standard geometry the crack initiation was always away from the center of the tablet.

Files in this item

Name:
I2M_IJP_Guerard_2016.pdf
Size:
2.555Mb
Format:
PDF
View/Open

Collections

  • Institut de Mécanique et d’Ingénierie de Bordeaux (I2M)

Related items

Showing items related by title, author, creator and subject.

  • Breaking pharmaceutical tablets with a hole: Reevaluation of the stress concentration factor and influence of the hole size 
    Article dans une revue avec comité de lecture
    CROQUELOIS, Benjamin; ccGIRARDOT, Jeremie; ccKOPP, Jean-Benoit; CAZAUTETS, Clément; TCHORELOFF, Pierre; MAZEL, Vincent (Elsevier, 2017)
    Mechanical strength is an important property for pharmaceutical tablets. Its study using the theory of linear elastic fracture mechanics has been introduced in the pharmaceutical field through the Brittle Fracture Index ...
  • Comparing failure tests on pharmaceutical tablets: Interpretation using experimental results and a numerical approach with cohesive zone models 
    Article dans une revue avec comité de lecture
    ccMAZEL, Vincent; ccGIRARDOT , Jeremie; ccKOPP, Jean-Benoit; MOREL, Stéphane; TCHORELOFF, Pierre (Elsevier BV, 2023-07)
    The mechanical strength is an important quality attribute of pharmaceutical tablets. It can be determined using different failure tests like the Brazilian test or the three-point bending test. Nevertheless, literature shows ...
  • Reinforcement of cellular materials with short fibres: Application to a bio-based cork multi-scale foam 
    Article dans une revue avec comité de lecture
    LE BARBENCHON, Louise; ccKOPP, Jean-Benoit; ccGIRARDOT, Jeremie; ccVIOT, Philippe (Elsevier, 2020)
    A bio-sourced foam, agglomerated cork, was chosen to evaluate the influence of short fibres on the mechanical behaviour of cellular materials. The final material was obtained by mixing cork particles with a thermoset resin. ...
  • Study of the dynamic fracture of hollow spheres under compression using the Discrete Element Method 
    Article dans une revue avec comité de lecture
    CORE, Arthur; ccKOPP, Jean-Benoit; ccGIRARDOT, Jeremie; ccVIOT, Philippe (ESIS - Elsevier, 2018)
    Hollow sphere structure (HSS) belongs to cellular solids that have been studied recently for its multiples properties. In our case, HSS aims to absorb soft impacts energy on an airliner cockpit. This structure is investigated ...
  • Multi-scale foam : 3D structure/compressive behaviour relationship of agglomerated cork 
    Article dans une revue avec comité de lecture
    LE BARBENCHON, Louise; ccGIRARDOT, Jeremie; ccKOPP, Jean-Benoit; ccVIOT, Philippe (Elsevier, 2019)
    This study focuses on the microstructural aspects of a cork-based by-product known as agglomerated cork and its influence on the compressive mechanical behaviour. The material consists in granulates of a natural polymeric ...

Browse

All SAMCommunities & CollectionsAuthorsIssue DateCenter / InstitutionThis CollectionAuthorsIssue DateCenter / Institution

Newsletter

Latest newsletterPrevious newsletters

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

ÉCOLE NATIONALE SUPERIEURE D'ARTS ET METIERS

  • Contact
  • Mentions légales

ÉCOLE NATIONALE SUPERIEURE D'ARTS ET METIERS

  • Contact
  • Mentions légales