Reevaluation of the diametral compression test for tablets using the flattened disc geometry
TypeArticles dans des revues avec comité de lecture
Mechanical strength is an important critical quality attribute for tablets. It is classically measured, in the pharmaceutical field, using the diametral compression test. Nevertheless, due to small contact area between the tablet and the platens, some authors suggested that during the test, the failure could occur in tension away from the center which would invalidate the test and the calculation of the tensile strength. In this study, the flattened disc geometry was used as an alternative to avoid contact problems. The diametral compression on both flattened and standard geometries was first studied using finite element method (FEM) simulation. It was found that, for the flattened geometry, both maximum tensile strain and stress were located at the center of the tablet, which was not the case for the standard geometry. Experimental observations using digital image correlation (DIC) confirmed the numerical results. The experimental tensile strength obtained using both geometries were compared and it was found that the standard geometry always gave lower tensile strength than the flattened geometry. Finally, high-speed video capture of the test made it possible to detect that for the standard geometry the crack initiation was always away from the center of the tablet.
Showing items related by title, author, creator and subject.
BENOIT, Aurélie; GUERARD, Sandra; GILLET, Brigitte; GUILLOT, Geneviève; HILD, François; MITTON, David; PERIE, Jean Noël; ROUX, Stéphane (elsevier, 2009)A mini-compression jig was built to perform in situ tests on bovine trabecular bone monitored by micro-MRI. The MRI antenna provided an isotropic resolution of 78 microm that allows for a volume correlation method to be ...
GUINARD, Caroline; GUIPONT, Vincent; JEANDIN, Michel; MONTAY, Guillaume; GIRARDOT, Jérémie; SCHNEIDER, Matthieu (ASM International, 2014)The gas turbine combustion chamber of aero-engines requires a thermal barrier coating (TBC) by thermal spraying. Further heat protection is achieved by laser drilling of cooling holes. The residual stresses play an important ...
Semi-automated stereoradiographic upper limb 3D reconstructions using a combined parametric and statistical model: a preliminary study LEBAILLY, Fréderic; LIMA, Lucas; CLAIREMIDI, Alain; AUBERT, Benjamin; GUERARD, Sandra; CHAÏBI, Yasmina; DE GUISE, Jacques; FONTAINE, Christian; SKALLI, Wafa (springer, 2012)PURPOSE: Quantitative assessment of 3D clinical indices may be crucial for elbow surgery planning. 3D parametric modeling from bi-planar radiographs was successfully proposed for spine and lower limb clinical investigation ...
GUERARD, Sandra; BAROU, Jean-Luc; PETIT, Julien; POISSON, Philippe (2014)This study examined whether the thermo-modeling process suits the thermal properties of the material constituting mouthformed mouthguards (MGs). Five mouth-formed MGs were compared: four commercially available MGs (SDITM, ...
BAIZ, Sarah; TSENG, Qingzong; PERQUIS, Lucie; OCTON, Jean; RHONÉ, Benoît; COSCOY, Sylvie; AMBLARD, François; SEMETE, Vincent (American Institute of Physics Inc., 2018)Cells are able to develop various types of membrane protrusions that modulate their adhesive, migratory, or functional properties. However, their ability to form basal protrusions, particularly in the context of epithelial ...