• français
    • English
    français
  • Login
Help
View Item 
  •   Home
  • Institut de Mécanique et d’Ingénierie de Bordeaux (I2M)
  • View Item
  • Home
  • Institut de Mécanique et d’Ingénierie de Bordeaux (I2M)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Breaking pharmaceutical tablets with a hole: Reevaluation of the stress concentration factor and influence of the hole size

Article dans une revue avec comité de lecture
Author
CROQUELOIS, Benjamin
ccGIRARDOT, Jeremie
ccKOPP, Jean-Benoit
CAZAUTETS, Clément
TCHORELOFF, Pierre
MAZEL, Vincent

URI
http://hdl.handle.net/10985/17336
DOI
10.1016/j.powtec.2017.04.033
Date
2017
Journal
Powder Technology

Abstract

Mechanical strength is an important property for pharmaceutical tablets. Its study using the theory of linear elastic fracture mechanics has been introduced in the pharmaceutical field through the Brittle Fracture Index (BFI). This index is based on the stress concentration factor (SCF) and contradictory results have been published in the pharmaceutical literature about the value of the SCF during the diametral compression of a disc with a hole. In this work, thanks to the use of numerical simulations (FEM) and analytical results, the value of the SCF was proved to be equal to 6. The result was also applicable for the case of the flattened disc geometry that was introduced in a previous work. The value of the SCF is found to be nearly independent of the hole size if the ratio between the hole and the tablet diameterswas lower than 0.1. Nevertheless, experimental results presented in this paper show that the load needed to break a compact varieswith the hole size. This influence is due to the change in the stress distribution around the hole when the hole size is changing. Criteria such as the average stress criterion, which takes into account the stress distribution, made it possible to explain the influence of the hole on the breaking load.

Files in this item

Name:
I2M_PT_2017_GIRARDOT.pdf
Size:
980.6Kb
Format:
PDF
View/Open

Collections

  • Institut de Mécanique et d’Ingénierie de Bordeaux (I2M)

Related items

Showing items related by title, author, creator and subject.

  • Reevaluation of the diametral compression test for tablets using the flattened disc geometry 
    Article dans une revue avec comité de lecture
    MAZEL, Vincent; ccGUÉRARD, Sandra; CROQUELOIS, Benjamin; ccKOPP, Jean-Benoit; ccGIRARDOT, Jeremie; DIARRA, Harona; BUSIGNIES, Virginie; TCHORELOFF, Pierre (Elsevier, 2016)
    Mechanical strength is an important critical quality attribute for tablets. It is classically measured, in the pharmaceutical field, using the diametral compression test. Nevertheless, due to small contact area between the ...
  • Comparing failure tests on pharmaceutical tablets: Interpretation using experimental results and a numerical approach with cohesive zone models 
    Article dans une revue avec comité de lecture
    ccMAZEL, Vincent; ccGIRARDOT , Jeremie; ccKOPP, Jean-Benoit; MOREL, Stéphane; TCHORELOFF, Pierre (Elsevier BV, 2023-07)
    The mechanical strength is an important quality attribute of pharmaceutical tablets. It can be determined using different failure tests like the Brazilian test or the three-point bending test. Nevertheless, literature shows ...
  • A damaging beam-lattice model for quasi-brittle fracture 
    Article dans une revue avec comité de lecture
    SAGE, Margaux; ccGIRARDOT, Jeremie; ccKOPP, Jean-Benoit; MOREL, Stéphane (Elsevier BV, 2022)
    This work aims to propose a new damaging beam-lattice model using the Discrete Element Method paradigm dedicated to the simulation of quasi-brittle fracture under complex loadings. Enrichment of the elastic Euler–Bernoulli ...
  • Energy Absorption Capacity of Agglomerated Cork Under Severe Loading Conditions 
    Article dans une revue avec comité de lecture
    ccLE BARBENCHON, Louise; ccVIOT, Philippe; ccGIRARDOT, Jeremie; ccKOPP, Jean-Benoit (Springer, 2021)
    Understanding the mechanical behavior of materials in working conditions is a current problem in transport industries. In this article, we demonstrate why the temperature and the strain-rate are first-order parameters when ...
  • Dynamic Fracture of a Semi-Crystalline Bio-Based Polymer Pipe: Effect of Temperature 
    Article dans une revue avec comité de lecture
    ccKOPP, Jean-Benoit; ccGIRARDOT, Jeremie (Scientific Research Publishing, Inc., 2021)
    The influence of temperature on the resistance to rapid crack propagation of a semi-crystalline bio-based polymer was studied. The experimental results described in this study allow to initiate a first discussion ...

Browse

All SAMCommunities & CollectionsAuthorsIssue DateCenter / InstitutionThis CollectionAuthorsIssue DateCenter / Institution

Newsletter

Latest newsletterPrevious newsletters

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

ÉCOLE NATIONALE SUPERIEURE D'ARTS ET METIERS

  • Contact
  • Mentions légales

ÉCOLE NATIONALE SUPERIEURE D'ARTS ET METIERS

  • Contact
  • Mentions légales