Breaking pharmaceutical tablets with a hole: Reevaluation of the stress concentration factor and influence of the hole size
TypeArticles dans des revues avec comité de lecture
Mechanical strength is an important property for pharmaceutical tablets. Its study using the theory of linear elastic fracture mechanics has been introduced in the pharmaceutical field through the Brittle Fracture Index (BFI). This index is based on the stress concentration factor (SCF) and contradictory results have been published in the pharmaceutical literature about the value of the SCF during the diametral compression of a disc with a hole. In this work, thanks to the use of numerical simulations (FEM) and analytical results, the value of the SCF was proved to be equal to 6. The result was also applicable for the case of the flattened disc geometry that was introduced in a previous work. The value of the SCF is found to be nearly independent of the hole size if the ratio between the hole and the tablet diameterswas lower than 0.1. Nevertheless, experimental results presented in this paper show that the load needed to break a compact varieswith the hole size. This influence is due to the change in the stress distribution around the hole when the hole size is changing. Criteria such as the average stress criterion, which takes into account the stress distribution, made it possible to explain the influence of the hole on the breaking load.
Showing items related by title, author, creator and subject.
MAZEL, Vincent; GUERARD, Sandra; CROQUELOIS, Benjamin; KOPP, Jean-Benoit; GIRARDOT, Jérémie; DIARRA, Harona; BUSIGNIES, Virginie; TCHORELOFF, Pierre (Elsevier, 2016)Mechanical strength is an important critical quality attribute for tablets. It is classically measured, in the pharmaceutical field, using the diametral compression test. Nevertheless, due to small contact area between the ...
Study of the dynamic fracture of hollow spheres under compression using the Discrete Element Method CORE, Arthur; KOPP, Jean-Benoit; GIRARDOT, Jérémie; VIOT, Philippe (ELSEVIER, 2018)Hollow sphere structure (HSS) belongs to cellular solids that have been studied recently for its multiples properties. In our case, HSS aims to absorb soft impacts energy on an airliner cockpit. This structure is investigated ...
Strain rate effect on the mechanical properties of a glass fibre reinforced acrylic matrix laminate. An experimental approach CADIEU, Lucien; KOPP, Jean-Benoit; JUMEL, Julien; BEGA, Jéremy; FROUSTEY, Catherine (Elsevier BV, 2019)The aim of this study is to evaluate the effect of the loading rate on the mechanical properties and damage mechanisms of a Glass/Elium150 laminate composite. Quasi-static indentation (QS) and low energy dynamic impact ...
A self-affine geometrical model of dynamic RT-PMMA fractures: implications for fracture energy measurements KOPP, Jean-Benoit; SCHMITTBUHL, Jean; NOEL, Olivier; FOND, Christophe (Springer, 2015)Profilometric imaging of fracture surfaces of rubber toughened polymer has been performed at two different resolutions (a) at large scales [10 μ\upmu m–25 mm] using an opto-mechanical profilometer and (b) at small scales ...
Experimental Investigation and Discrete Element Modelling of Composite Hollow Spheres Subjected to Dynamic Fracture CORE, Arthur; KOPP, Jean-Benoit; VIOT, Philippe; CHARLES, Jean-Luc; DAU, Frédéric (Hindawi Limited, 2017)This paper deals with the characterization and the numerical modelling of the collapse of composite hollow spherical structures developed to absorb energy during high velocity impacts. The structure is composed of hollow ...