Simulating the Remodelling of Bone around Implants
TypeCommunications sans actes
Introduction Improper osseointegration of implants leading to poor mechanical anchoring or embrittlement of neighboring bone is a major concern in orthopedic surgery [1?]. This integration is known to depend on the complex interplay between the mechanical environment and the cell activity in the tissues surrounding the implant. In order to accurately predict the success of an implant a robust description of the remodeling behavior of bone is required. Building upon previous research modeling osteogenesis around implants  a mechano-biological Finite Element (FE) model is proposed to describe the remodeling processes involved when bone, cartilage and fibrous tissue are submitted to mechanical loads. Method In this work, we describe the mechanostat (the interrelationship between loading conditions and remodeling) of bone  by modelling the net effect of cellular activities at the tissue level. For that, we distinguish the immature tissues resulting from the early proliferation steps (growth and diffusion) from the mature tissues obtained after a consolidation of the extra-cellular matrix (mineralization for bone). In each elementary volume element, the creation of new (immature) tissue is dependent upon the level of applied strain and is described by a reaction-diffusion equation. Results Using these equations a simple cantilever cyclic bending simulation was created and loaded to recreate a range of physiological strains experienced during bone remodeling. Preliminary results for bone tissue only are presented in Figure 1. This shows the cantilever boundary conditions and maximum normalized shear strain distribution which produce the evolution of immature and mature bone tissues over time. As the Young’s modulus increases proportionately with the increase in mature tissue density the strain under constant loading conditions is observed to reduce, therefore altering the generation of new tissue types. The model proposed here may offer numerous perspectives as a predictive tool for implant design or for the new therapies against bone resorption.
Showing items related by title, author, creator and subject.
Subject specific hexahedral Finite Element mesh generation of the pelvis from bi-Planar X-ray images FOUGERON, Nolwenn; PILLET, Hélène; SKALLI, Wafa; ROHAN, Pierre-Yves (Informa UK Limited, 2017-10-27)Several Finite Element (FE) models of the pelvis have been developed to comprehensively assess the onset of pathologies and for clinical and industrial applications. However, because of the difficulties associated with ...
Subject Specific Finite Element Mesh Generation of the Pelvis from Biplanar X-ray Images: Application to 120 clinical cases FOUGERON, Nolwenn; ROHAN, Pierre-Yves; MACRON, Aurélien; TRAVERT, Christophe; PILLET, Hélène; SKALLI, Wafa (2018-07-03)Several Finite Element (FE) models of the pelvis have been developed to comprehensively assess the onset of pathologies and for clinical and industrial applications. However, because of the difficulties associated with the ...
In vivo identification of the mechanical properties of thigh tissues from FreeHand Ultrasound for the numerical investigation of loads at the socket/residual limb interface of amputee people FOUGERON, Nolwenn; BONNET, Xavier; ROSE, Jean-Loïc; ROHAN, Pierre-Yves; PILLET, Hélène (2019)Prosthetic sockets are custom-designed and are decisive for functionality and comfort of limb prosthesis. To ensure load transmission and stability, high interface stresses are applied. Several computer models of the ...
BIJAR, Ahmad; ROHAN, Pierre-Yves; PERRIER, Pascal; PAYAN, Yohan (Springer Science and Business Media LLC, 2015-11-17)Generation of subject-specific 3D finite element (FE) models requires the processing of numerous medical images in order to precisely extract geometrical information about subject-specific anatomy. This processing remains ...
Role of Ligaments in the Knee Joint Kinematic Behavior: Development and Validation of a Finite Element Model GERMAIN, F.; ROHAN, Pierre-Yves; ROCHCONGAR, G.; ROUCH, Philippe; THOREUX, P.; PILLET, Hélène; SKALLI, Wafa (Springer International Publishing, 2016-06-16)The management of knee instability is a complex problem in orthopedic surgery. To comprehensively assess the biomechanical role of the knee joint and to investigate various aspects of knee mechanics, several Finite Element ...