A Cellular Potts Model of single cell migration in presence of durotaxis
TypeArticles dans des revues avec comité de lecture
Cell migration is a fundamental biological phenomenon during which cells sense their surroundings and respond to different types of signals. In presence of durotaxis, cells preferentially crawl from soft to stiffsubstrates by reorganizing their cytoskeleton from an isotropic to an anisotropic distribution of actin fil- aments. In the present paper, we propose a Cellular Potts Model to simulate single cell migration over flat substrates with variable stiffness. We have tested five configurations: (i) a substrate including a soft and a stiffregion, (ii) a soft substrate including two parallel stiffstripes, (iii) a substrate made of succes- sive stripes with increasing stiffness to create a gradient and (iv) a stiffsubstrate with four embedded soft squares. For each simulation, we have evaluated the morphology of the cell, the distance covered, the spreading area and the migration speed. We have then compared the numerical results to specific experimental observations showing a consistent agreement.
Cette publication figure dans le(s) laboratoire(s) suivant(s)
Visualiser des documents liés par titre, auteur, créateur et sujet.
AUBRY, Denis; GUPTA, M.; LADOUX, B.; ALLENA, Rachele (IOPScience, 2015)Cell migration, a fundamental mechanobiological process, is highly sensitive to the biochemical and mechanical properties of the environment. Efficient cell migration is ensured by the intrinsic polarity of the cell, which ...
Healthy vs. osteoarthritic hips: A comparison of hip, pelvis and femoral parameters and relationships using the EOS® system BENDAYA, Samy; LAZENNEC, Jean-Yves; ANGLIN, Carolyn; ALLENA, Rachele; SELLAM, N.; THOUMIE, P.; SKALLI, Wafa (Elsevier, 2015)Osteoarthritis is a debilitating disease, for which the development path is unknown. Hip, pelvis and femoral morphological and positional parameters relate either to individual differences or to changes in the disease ...
A computational mechanics approach to assess the link between cell morphology and forces during confined migration AUBRY, Denis; THIAM, Hawa; PIEL, Matthieu; ALLENA, Rachele (Springer, 2014)Confined migration plays a fundamental role during several biological phenomena such as embryogenesis, immunity and tumorogenesis. Here, we propose a two-dimensional mechanical model to simulate the migration of a HeLa ...
ALLENA, Rachele; CLUZEL, Christophe (Elsevier, 2014)For a proper analysis of cortical bone behaviour, it is essential to take into account both the elastic stiffness and the failure criteria. While ultrasound methods allow complete identification of the elastic orthotropic ...
Reaction–Diffusion Finite Element Model of Lateral Line Primordium Migration to Explore Cell Leadership ALLENA, Rachele; MAINI, Philip (Springer, 2014)Collective cell migration plays a fundamental role in many biological phenomena such as immune response, embryogenesis and tumorigenesis. In the present work, we propose a reaction–diffusion finite element model of the ...