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A Cellular Potts Model of single cell migration in presence of durotaxis

Article dans une revue avec comité de lecture
Auteur
ALLENA, Rachele
466360 Institut de Biomecanique Humaine Georges Charpak
SCIANNA, Marco
6571 Politecnico di Torino = Polytechnic of Turin [Polito]
PREZIOSI, Luigi
6571 Politecnico di Torino = Polytechnic of Turin [Polito]

URI
http://hdl.handle.net/10985/17440
DOI
10.1016/j.mbs.2016.02.011
Date
2016
Journal
Mathematical Biosciences

Résumé

Cell migration is a fundamental biological phenomenon during which cells sense their surroundings and respond to different types of signals. In presence of durotaxis, cells preferentially crawl from soft to stiffsubstrates by reorganizing their cytoskeleton from an isotropic to an anisotropic distribution of actin fil- aments. In the present paper, we propose a Cellular Potts Model to simulate single cell migration over flat substrates with variable stiffness. We have tested five configurations: (i) a substrate including a soft and a stiffregion, (ii) a soft substrate including two parallel stiffstripes, (iii) a substrate made of succes- sive stripes with increasing stiffness to create a gradient and (iv) a stiffsubstrate with four embedded soft squares. For each simulation, we have evaluated the morphology of the cell, the distance covered, the spreading area and the migration speed. We have then compared the numerical results to specific experimental observations showing a consistent agreement.

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  • Institut de Biomécanique Humaine Georges Charpak (IBHGC)

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    Article dans une revue avec comité de lecture
    ALLENA, Rachele (Springer Verlag, 2013)
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    Article dans une revue avec comité de lecture
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