• français
    • English
    français
  • Login
Help
View Item 
  •   Home
  • Institut de Biomécanique Humaine Georges Charpak (IBHGC)
  • View Item
  • Home
  • Institut de Biomécanique Humaine Georges Charpak (IBHGC)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Cell Migration with Multiple Pseudopodia : Temporal and Spatial Sensing Models

Article dans une revue avec comité de lecture
Author
ALLENA, Rachele
99538 Laboratoire de biomécanique [LBM]

URI
http://hdl.handle.net/10985/8580
DOI
10.1007/s11538-012-9806-1
Date
2013
Journal
Bulletin of Mathematical Biology

Abstract

Cell migration triggered by pseudopodia (or “false feet”) is the most used method of locomotion. A 3D finite element model of a cell migrating over a 2D substrate is proposed, with a particular focus on the mechanical aspects of the biological phenomenon. The decomposition of the deformation gradient is used to reproduce the cyclic phases of protrusion and contraction of the cell, which are tightly synchronized with the adhesion forces at the back and at the front of the cell, respectively. First, a steady active deformation is considered to show the ability of the cell to simultaneously initiate multiple pseudopodia. Here, randomness is considered as a key aspect, which controls both the direction and the amplitude of the false feet. Second, the migration process is described through two different strategies: the temporal and the spatial sensing models. In the temporal model, the cell “sniffs” the surroundings by extending several pseudopodia and only the one that receives a positive input will become the new leading edge, while the others retract. In the spatial model instead, the cell senses the external sources at different spots of the membrane and only protrudes one pseudopod in the direction of the most attractive one.

Files in this item

Name:
LBM_BMB_ALLENA_2013.pdf
Size:
2.024Mb
Format:
PDF
View/Open

Collections

  • Institut de Biomécanique Humaine Georges Charpak (IBHGC)

Related items

Showing items related by title, author, creator and subject.

  • On the mechanical interplay between intra- and inter-synchronization during collective cell migration : a numerical investigation 
    Article dans une revue avec comité de lecture
    ALLENA, Rachele; AUBRY, Denis; SHARPE, James (Springer Verlag, 2013)
    Collective cell migration is a fundamental process that takes place during several biological phenomena such as embryogenesis, immunity response, and tumorogenesis, but the mechanisms that regulate it are still unclear. ...
  • Diffusion model to describe osteogenesis within a porous titanium scaffold. 
    Article dans une revue avec comité de lecture
    SCHMITT, M.; ALLENA, Rachele; SCHOUMAN, T.; FRASCA, S.; COLLOMBET, J.M.; HOLY, X.; ccROUCH, Philippe (Taylor & Francis, 2015)
    In this study, we develop a two-dimensional finite element model, which is derived from an animal experiment and allows simulating osteogenesis within a porous titanium scaffold implanted in ewe's hemi-mandible during 12 ...
  • Healthy vs. osteoarthritic hips: A comparison of hip, pelvis and femoral parameters and relationships using the EOS® system 
    Article dans une revue avec comité de lecture
    BENDAYA, Samy; LAZENNEC, Jean-Yves; ANGLIN, Carolyn; ALLENA, Rachele; SELLAM, N.; THOUMIE, P.; ccSKALLI, Wafa (Elsevier, 2015)
    Osteoarthritis is a debilitating disease, for which the development path is unknown. Hip, pelvis and femoral morphological and positional parameters relate either to individual differences or to changes in the disease ...
  • Mechanical modelling of confined cell migration across constricted-curved micro-channels 
    Article dans une revue avec comité de lecture
    ALLENA, Rachele (Tech Science Press, 2014)
    Confined migration is a crucial phenomenon during embryogenesis, immune response and cancer. Here, a two-dimensional finite element model of a HeLa cell migrating across constricted-curved micro-channels is proposed. The ...
  • Mechanical link between durotaxis, cell polarity and anisotropy during cell migration 
    Article dans une revue avec comité de lecture
    AUBRY, Denis; GUPTA, M.; LADOUX, B.; ALLENA, Rachele (Institute of Physics: Hybrid Open Access, 2015)
    Cell migration, a fundamental mechanobiological process, is highly sensitive to the biochemical and mechanical properties of the environment. Efficient cell migration is ensured by the intrinsic polarity of the cell, which ...

Browse

All SAMCommunities & CollectionsAuthorsIssue DateCenter / InstitutionThis CollectionAuthorsIssue DateCenter / Institution

Newsletter

Latest newsletterPrevious newsletters

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

ÉCOLE NATIONALE SUPERIEURE D'ARTS ET METIERS

  • Contact
  • Mentions légales

ÉCOLE NATIONALE SUPERIEURE D'ARTS ET METIERS

  • Contact
  • Mentions légales