• français
    • English
    English
  • Ouvrir une session
Aide
Voir le document 
  •   Accueil de SAM
  • Institut de Biomécanique Humaine Georges Charpak (IBHGC)
  • Voir le document
  • Accueil de SAM
  • Institut de Biomécanique Humaine Georges Charpak (IBHGC)
  • Voir le document
JavaScript is disabled for your browser. Some features of this site may not work without it.

Cell Migration with Multiple Pseudopodia : Temporal and Spatial Sensing Models

Article dans une revue avec comité de lecture
Auteur
ALLENA, Rachele
99538 Laboratoire de biomécanique [LBM]

URI
http://hdl.handle.net/10985/8580
DOI
10.1007/s11538-012-9806-1
Date
2013
Journal
Bulletin of Mathematical Biology

Résumé

Cell migration triggered by pseudopodia (or “false feet”) is the most used method of locomotion. A 3D finite element model of a cell migrating over a 2D substrate is proposed, with a particular focus on the mechanical aspects of the biological phenomenon. The decomposition of the deformation gradient is used to reproduce the cyclic phases of protrusion and contraction of the cell, which are tightly synchronized with the adhesion forces at the back and at the front of the cell, respectively. First, a steady active deformation is considered to show the ability of the cell to simultaneously initiate multiple pseudopodia. Here, randomness is considered as a key aspect, which controls both the direction and the amplitude of the false feet. Second, the migration process is described through two different strategies: the temporal and the spatial sensing models. In the temporal model, the cell “sniffs” the surroundings by extending several pseudopodia and only the one that receives a positive input will become the new leading edge, while the others retract. In the spatial model instead, the cell senses the external sources at different spots of the membrane and only protrudes one pseudopod in the direction of the most attractive one.

Fichier(s) constituant cette publication

Nom:
LBM_BMB_ALLENA_2013.pdf
Taille:
2.024Mo
Format:
PDF
Voir/Ouvrir

Cette publication figure dans le(s) laboratoire(s) suivant(s)

  • Institut de Biomécanique Humaine Georges Charpak (IBHGC)

Documents liés

Visualiser des documents liés par titre, auteur, créateur et sujet.

  • Diffusion model to describe osteogenesis within a porous titanium scaffold. 
    Article dans une revue avec comité de lecture
    SCHMITT, M.; ALLENA, Rachele; SCHOUMAN, T.; FRASCA, S.; COLLOMBET, J.M.; HOLY, X.; ccROUCH, Philippe (Taylor & Francis, 2015)
    In this study, we develop a two-dimensional finite element model, which is derived from an animal experiment and allows simulating osteogenesis within a porous titanium scaffold implanted in ewe's hemi-mandible during 12 ...
  • Mechanical link between durotaxis, cell polarity and anisotropy during cell migration 
    Article dans une revue avec comité de lecture
    AUBRY, Denis; GUPTA, M.; LADOUX, B.; ALLENA, Rachele (Institute of Physics: Hybrid Open Access, 2015)
    Cell migration, a fundamental mechanobiological process, is highly sensitive to the biochemical and mechanical properties of the environment. Efficient cell migration is ensured by the intrinsic polarity of the cell, which ...
  • Identification of anisotropic tensile strength of cortical bone using Brazilian test. 
    Article dans une revue avec comité de lecture
    ALLENA, Rachele; CLUZEL, Christophe (Elsevier, 2014)
    For a proper analysis of cortical bone behaviour, it is essential to take into account both the elastic stiffness and the failure criteria. While ultrasound methods allow complete identification of the elastic orthotropic ...
  • Mechanical modelling of confined cell migration across constricted-curved micro-channels 
    Article dans une revue avec comité de lecture
    ALLENA, Rachele (Tech Science Press, 2014)
    Confined migration is a crucial phenomenon during embryogenesis, immune response and cancer. Here, a two-dimensional finite element model of a HeLa cell migrating across constricted-curved micro-channels is proposed. The ...
  • Reaction–Diffusion Finite Element Model of Lateral Line Primordium Migration to Explore Cell Leadership 
    Article dans une revue avec comité de lecture
    ALLENA, Rachele; MAINI, Philip (Springer Verlag, 2014)
    Collective cell migration plays a fundamental role in many biological phenomena such as immune response, embryogenesis and tumorigenesis. In the present work, we propose a reaction–diffusion finite element model of the ...

Parcourir

Tout SAMLaboratoiresAuteursDates de publicationCampus/InstitutsCe LaboratoireAuteursDates de publicationCampus/Instituts

Lettre Diffuser la Science

Dernière lettreVoir plus

Statistiques de consultation

Publications les plus consultéesStatistiques par paysAuteurs les plus consultés

ÉCOLE NATIONALE SUPERIEURE D'ARTS ET METIERS

  • Contact
  • Mentions légales

ÉCOLE NATIONALE SUPERIEURE D'ARTS ET METIERS

  • Contact
  • Mentions légales