Cell nutriments and motility for mechanobiological bone remodeling in the context of orthodontic periodontal ligament deformation
Article dans une revue avec comité de lecture
Bone remodeling is a complex phenomenon during which old and new bone is continuously removed and replaced. This phenomenon involves several processes at different length scales such as mechanical, biological, molecular, and chemicals. In the current work, we study the influence of the biological (cells) and molecular (oxygen and glucose) factors coupled with mechanical loads in order to predict bone remodeling for orthodontic treatments. A coupled theoretical mechanobiological model is proposed to extract the oxygen variation due to the deformation of the periodontal ligament leading to cell differentiation and activation. The mechanobiological stimulus is then calculated. The model is applied on a simplified two dimensional geometry to highlight the density variations and migrations of cells and molecular factors influencing the bone remodeling process.
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Article dans une revue avec comité de lectureGEORGE, Daniel; ALLENA, Rachele; REMOND, Yves (Taylor & Francis, 2017)Mechanobiological stimuli for bone remodeling: mechanical energy, cell nutriments and mobility
Article dans une revue avec comité de lectureGEORGE, Daniel; ALLENA, Rachele; REMOND, Yves (International Research Center for Mathematics & Mechanics of Complex Systems (M&MoCS),University of L’Aquila in Italy, 2018)Bone remodelling is a complex phenomenon during which old and damage bone is removed and replaced with new one to ensure the physiological functions of the skeletal system. It involves many biological, mechanical, chemical ...
Integrating molecular and cellular kinetics into a coupled continuum mechanobiological stimulus for bone reconstruction Article dans une revue avec comité de lectureGEORGE, Daniel; ALLENA, Rachele; REMOND, Yves (Springer Verlag, 2018)The development of multiphysics numerical models to predict bone reconstruction is a very challenging task as it is a complex phenomenon where many biological, chemical and mechanical processes occur at different lengths ...
A new comprehensive approach for bone remodeling under medium and high mechanical load based on cellular activity Article dans une revue avec comité de lectureALLENA, Rachele; GEORGE, Daniel; BOURZAC, Céline; PALLU, Stéphane; RÉMOND, Yves; BENSIDHOUM, Morad; PORTIER, Hugues (International Research Center for Mathematics & Mechanics of Complex Systems (M&MoCS),University of L’Aquila in Italy, 2020)Most of the last century, bone remodeling models have been proposed based on the observation that bone density is dependent on the intensity of the applied mechanical loads. Most of these cortical or trabecular bone ...
A preliminary approach in the prediction of orthodontic bone remodeling by coupling experiments, theory and numerical models Article dans une revue avec comité de lectureGEORGE, Daniel; WAGNER, Delphine; BOLENDER, Yves; LAHEURTE, Pascal; PIOTROWSKI, Boris; DIDIER, Paul; BENSIDHOUM, Morad; HERBERT, Valentin; SPINGARN, Camille; RÉMOND, Yves (Informa UK Limited, 2020)Orthodontic treatments are based on a prolonged application of mechanical forces on the teeth through orthodontic appliances, leading to tooth movement due to the remodeling of the surrounding bone. Bone response is dependent ...