Cell nutriments and motility for mechanobiological bone remodeling in the context of orthodontic periodontal ligament deformation
TypeArticles dans des revues avec comité de lecture
Bone remodeling is a complex phenomenon during which old and new bone is continuously removed and replaced. This phenomenon involves several processes at different length scales such as mechanical, biological, molecular, and chemicals. In the current work, we study the influence of the biological (cells) and molecular (oxygen and glucose) factors coupled with mechanical loads in order to predict bone remodeling for orthodontic treatments. A coupled theoretical mechanobiological model is proposed to extract the oxygen variation due to the deformation of the periodontal ligament leading to cell differentiation and activation. The mechanobiological stimulus is then calculated. The model is applied on a simplified two dimensional geometry to highlight the density variations and migrations of cells and molecular factors influencing the bone remodeling process.
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GEORGE, Daniel; ALLENA, Rachele; REMOND, Yves (International Research Center for the Mathematics and Mechanics of Complex Systems - Università Dell’Aquila, Italy, 2018)Bone remodelling is a complex phenomenon during which old and damage bone is removed and replaced with new one to ensure the physiological functions of the skeletal system. It involves many biological, mechanical, chemical ...
GEORGE, Daniel; ALLENA, Rachele; REMOND, Yves (2017)Mechanobiological stimuli for bone remodeling: mechanical energy, cell nutriments and mobility
Integrating molecular and cellular kinetics into a coupled continuum mechanobiological stimulus for bone reconstruction GEORGE, Daniel; ALLENA, Rachele; REMOND, Yves (Springer Verlag, 2018)The development of multiphysics numerical models to predict bone reconstruction is a very challenging task as it is a complex phenomenon where many biological, chemical and mechanical processes occur at different lengths ...
LAUZERAL, Nathan; BORZACCHIELLO, Domenico; KUGLER, Michaël; GEORGE, Daniel; RÉMOND, Yves; HOSTETTLER, Alexandre; CHINESTA, Francisco (TAYLOR & FRANCIS, 2019)The main objective of this study is to combine the statistical shape analysis with a morphing procedure in order to generate shape-parametric finite element models of tissues and organs and to explore the reliability and ...
A model order reduction approach to create patient-specific mechanical models of human liver in computational medicine applications. LAUZERAL, Nathan; BORZACCHIELLO, Domenico; KUGLER, Michael; RÉMOND, Yves; GEORGE, Daniel; HOSTETTLER, Alexandre; CHINESTA, Francisco (elsevier, 2019)Background and objective: This paper focuses on computer simulation aspects of Digital Twin models in the medical framework. In particular, it addresses the need of fast and accurate simulators for the mechanical response ...