Integrating molecular and cellular kinetics into a coupled continuum mechanobiological stimulus for bone reconstruction
TypeArticles dans des revues avec comité de lecture
The development of multiphysics numerical models to predict bone reconstruction is a very challenging task as it is a complex phenomenon where many biological, chemical and mechanical processes occur at different lengths and timescales.We present here amechanobiological theoretical numerical model accounting for both the mechanical and biological environments to predict the bone reconstruction process through the use of a global stimulus integrating the contributions of applied external mechanical loads, cellular activities and cellular nutriments such as oxygen and glucose supply. The bone density evolution will hence depend on the overall stimulus and evolve accordingly to the intensities of each of its individual constituents. We show their specific influences and couplings on a simple two-dimensional geometry and confirm that, although the mechanics plays a crucial role in the bone reconstruction process, it is still highly dependent on the occurring biological events and will evolve accordingly.
Showing items related by title, author, creator and subject.
GEORGE, Daniel; ALLENA, Rachele; REMOND, Yves (International Research Center for the Mathematics and Mechanics of Complex Systems - Università Dell’Aquila, Italy, 2018)Bone remodelling is a complex phenomenon during which old and damage bone is removed and replaced with new one to ensure the physiological functions of the skeletal system. It involves many biological, mechanical, chemical ...
Cell nutriments and motility for mechanobiological bone remodeling in the context of orthodontic periodontal ligament deformation GEORGE, Daniel; ALLENA, Rachele; REMOND, Yves (Elsevier, 2018)Bone remodeling is a complex phenomenon during which old and new bone is continuously removed and replaced. This phenomenon involves several processes at different length scales such as mechanical, biological, molecular, ...
GEORGE, Daniel; ALLENA, Rachele; REMOND, Yves (2017)Mechanobiological stimuli for bone remodeling: mechanical energy, cell nutriments and mobility
A new comprehensive approach for bone remodeling under medium and high mechanical load based on cellular activity ALLENA, Rachele; GEORGE, Daniel; BOURZAC, Céline; PALLU, Stéphane; RÉMOND, Yves; BENSIDHOUM, Morad; PORTIER, Hugues (Mathematical Sciences, 2020)Most of the last century, bone remodeling models have been proposed based on the observation that bone density is dependent on the intensity of the applied mechanical loads. Most of these cortical or trabecular bone ...
LAUZERAL, Nathan; BORZACCHIELLO, Domenico; KUGLER, Michaël; GEORGE, Daniel; RÉMOND, Yves; HOSTETTLER, Alexandre; CHINESTA, Francisco (TAYLOR & FRANCIS, 2019)The main objective of this study is to combine the statistical shape analysis with a morphing procedure in order to generate shape-parametric finite element models of tissues and organs and to explore the reliability and ...