• français
    • English
    français
  • Login
Help
View Item 
  •   Home
  • Laboratoire Procédés et Ingénierie en Mécanique et Matériaux (PIMM)
  • View Item
  • Home
  • Laboratoire Procédés et Ingénierie en Mécanique et Matériaux (PIMM)
  • View Item
JavaScript is disabled for your browser. Some features of this site may not work without it.

In vitro study of drug release from various loaded polyurethane samples and subjected to different non-pulsed flow rates

Article dans une revue avec comité de lecture
Author
ABBASNEZHAD, Navideh
86289 Laboratoire Procédés et Ingénierie en Mécanique et Matériaux [PIMM]
1003528 Laboratoire d'Ingénierie des Fluides et des Systèmes Énergétiques [LIFSE]
SHIRINBAYAN, Mohammadali
1003528 Laboratoire d'Ingénierie des Fluides et des Systèmes Énergétiques [LIFSE]
TCHARKHTCHI, Abbas
86289 Laboratoire Procédés et Ingénierie en Mécanique et Matériaux [PIMM]
BAKIR, Farid
1003528 Laboratoire d'Ingénierie des Fluides et des Systèmes Énergétiques [LIFSE]

URI
http://hdl.handle.net/10985/18479
DOI
10.1016/j.jddst.2020.101500
Date
2020
Journal
Journal of Drug Delivery Science and Technology

Abstract

Drug-eluting implants with a polymeric matrix are currently widely used and the interest of modeling their behavior is increasing. This article aims to present preliminary results of an in vitro under steady flow, study the behavior of drug-loaded polyurethane samples used as drug delivery matrices. Polyisocyanate and polyol synthesis supplied the polyurethane studied in this work. A molding and heat at 50 °C for about 30 min make it possible to prepare films from these components. The prepared samples are placed in the impermeable Plexiglas tube and they are in contact with the medium (distilled water). Tests have been performed without flow and three other cases with steady flow, at a temperature of 37 °C. The substance active incorporated in these films, as the drug, for carrying out the release tests is the C20H24C12N2O3. This drug supplied in granular form is composed of a mixture in the following proportions, 15 mg of diclofenac epolamine and 50 mg of diclofenac-sodium. Four sample variants were carefully prepared: pure-PU and PU loaded in a mass ratio of 10, 20 or 30%. Weighing, DSC, FT-IR, and DMTA are the methods used to analyze the samples. In addition, SEM micrographs are used to explore qualitatively the microstructure during the release tests. The kinetics in vitro of the drug release and water absorption by the polyurethane films are discussed in detail. The results show that these two quantities depend on the initial drug loading and the flow rate value, as a function of the in vitro incubation time.

Files in this item

Name:
PIMM_JDDST_2020_ABBASNEZHAD.pdf
Size:
3.809Mb
Format:
PDF
Description:
Article
Embargoed until:
2020-08-01
View/Open

Collections

  • Laboratoire Ingénierie des fluides Systèmes énergétiques (LIFSE)
  • Laboratoire Procédés et Ingénierie en Mécanique et Matériaux (PIMM)

Related items

Showing items related by title, author, creator and subject.

  • On the importance of physical and mechanical properties of PLGA films during drug release 
    Article dans une revue avec comité de lecture
    ABBASNEZHAD, Navideh; ZIRAK, Nader; SHIRINBAYAN, Mohammadali; TCHARKHTCHI, Abbas; BAKIR, Farid (Elsevier, 2021)
    Physical and mechanical properties of the drug-incorporated polymer play a significant role in the release behavior from the drug carriers. Understanding the relative extent of variation in the physical and mechanical ...
  • Controlled release from polyurethane films: Drug release mechanisms 
    Article dans une revue avec comité de lecture
    ABBASNEZHAD, Navideh; ZIRAK, Nader; SHIRINBAYAN, Mohammadali; KOUIDRI, Smaine; SALAHINEJAD, Erfan; TCHARKHTCHI, Abbas; BAKIR, Farid (Wiley, 2021)
    In this study, polyurethane-films loaded with diclofenac were used to analyze the drug release kinetics and mechanisms. For this purpose, the experimental procedures were developed under static and dynamic conditions with ...
  • Development of a Model Based on Physical Mechanisms for the Explanation of Drug Release: Application to Diclofenac Release from Polyurethane Films 
    Article dans une revue avec comité de lecture
    ABBASNEZHAD, Navideh; KEBDANI, Mohamed; SHIRINBAYAN, Mohammadali; CHAMPMARTIN, Stéphane; TCHARKHTCHI, Abbas; KOUIDRI, Smaine; BAKIR, Farid (MDPI AG, 2021)
    In this study, we present a method for prediction of the drug-release profile based on the physical mechanisms that can intervene in drug release from a drug-carrier. The application presented here incorporates the effects ...
  • Viscoelastic Behavior of Drug-Loaded Polyurethane 
    Article dans une revue avec comité de lecture
    ABBASNEZHAD, Navideh; SHIRINBAYAN, Mohammadali; CHABI, Fatiha; CHAMPMARTIN, Stephane; TCHARKHTCHI, Abbas; BAKIR, Farid (MDPI AG, 2021)
    Drug-eluting stents are desirable platforms for local medicine delivery. However, the incorporation of drugs into polymers can influence the mechanical and physicochemical properties of said matrix, which is a topic that ...
  • Rotational Molding of Polyamide-12 Nanocomposites: Modeling of the Viscoelastic Behavior 
    Article dans une revue avec comité de lecture
    SHIRINBAYAN, Mohammadali; MONTAZERI, A.; NOURI SEDEH, M.; ABBASNEZHAD, Navideh; FITOUSSI, Joseph; TCHARKHTCHI, Abbas (Springer Verlag, 2021)
    Nowadays, polyamide 12 (PA-12) is considered as an interesting polymer in the rotomolding process to manufacture different pieces like the liner part in the storage hydrogen tank (type IV). In this study, the pure polyamide-12 ...

Browse

All SAMCommunities & CollectionsAuthorsIssue DateCenter / InstitutionThis CollectionAuthorsIssue DateCenter / Institution

Newsletter

Latest newsletterPrevious newsletters

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

ÉCOLE NATIONALE SUPERIEURE D'ARTS ET METIERS

  • Contact
  • Mentions légales

ÉCOLE NATIONALE SUPERIEURE D'ARTS ET METIERS

  • Contact
  • Mentions légales