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On the importance of physical and mechanical properties of PLGA films during drug release

Article dans une revue avec comité de lecture
Author
ABBASNEZHAD, Navideh
86289 Laboratoire Procédés et Ingénierie en Mécanique et Matériaux [PIMM]
1003528 Laboratoire d'Ingénierie des Fluides et des Systèmes Énergétiques [LIFSE]
ZIRAK, Nader
1003528 Laboratoire d'Ingénierie des Fluides et des Systèmes Énergétiques [LIFSE]
SHIRINBAYAN, Mohammadali
86289 Laboratoire Procédés et Ingénierie en Mécanique et Matériaux [PIMM]
1003528 Laboratoire d'Ingénierie des Fluides et des Systèmes Énergétiques [LIFSE]
TCHARKHTCHI, Abbas
86289 Laboratoire Procédés et Ingénierie en Mécanique et Matériaux [PIMM]
BAKIR, Farid
1003528 Laboratoire d'Ingénierie des Fluides et des Systèmes Énergétiques [LIFSE]

URI
http://hdl.handle.net/10985/20155
DOI
10.1016/j.jddst.2021.102446
Date
2021
Journal
Journal of Drug Delivery Science and Technology

Abstract

Physical and mechanical properties of the drug-incorporated polymer play a significant role in the release behavior from the drug carriers. Understanding the relative extent of variation in the physical and mechanical properties of the polymer makes it possible to improve the design of polymer carriers to obtain better release profile and increase drug stability. Drug delivery from PLGA loaded with various percentages of diclofenac sodium (DS: 0, 5%, and 10%) at different flow rates of 0 and 7.5 ml/s (flow rate of the healthy internal carotid artery) in phosphate buffered saline (PBS) for different release intervals has been studied. In this research, the change of some physical properties such as free volume fraction, glass transition temperature (Tg) and mechanical properties before and during PLGA release have been investigated. In-vitro release tests have been performed in the PBS medium at the temperature of 37 °C. The results showed that during drug release, Youngs’ modulus and ultimate stress were increased while elongation at break was decreased for different drug loaded films and flow rates. In addition, the zero order kinetic model was found to best fit all the release-profiles obtained.

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  • Laboratoire Ingénierie des fluides Systèmes énergétiques (LIFSE)
  • Laboratoire Procédés et Ingénierie en Mécanique et Matériaux (PIMM)

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