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Viscoelastic Behavior of Drug-Loaded Polyurethane

Article dans une revue avec comité de lecture
Author
ABBASNEZHAD, Navideh
ccSHIRINBAYAN, Mohammadali
CHABI, Fatiha
ccCHAMPMARTIN, Stephane
ccTCHARKHTCHI, Abbas
86289 Laboratoire Procédés et Ingénierie en Mécanique et Matériaux [PIMM]
ccBAKIR, Farid
1003528 Laboratoire d'Ingénierie des Fluides et des Systèmes Énergétiques [LIFSE]

URI
http://hdl.handle.net/10985/20795
DOI
10.3390/polym13162608
Date
2021
Journal
Polymers

Abstract

Drug-eluting stents are desirable platforms for local medicine delivery. However, the incorporation of drugs into polymers can influence the mechanical and physicochemical properties of said matrix, which is a topic that is still poorly understood. In fact, this is more noticeable since the apposition is most often accompanied by mechanical stresses on the polymer coating, which can induce therapeutic failure that can result in death. It is therefore necessary to better understand their behavior by examining their properties in conditions such as those in living beings. We studied polyurethane drug carriers made in-house. Diclofenac epolamine was chosen as a model hydrophilic medicine. We used thermal measurements (DMTA) and tensile tests. The aim was to establish the influence of the loading and release of the drug on the physicochemical properties of this polymer in the presence of a stagnant or circulating fluid medium, phosphate-buffered saline (PBS). For the two PU/drug loadings studied, the effect of the initial drug load was more marked. The free volume fraction and the number of pores in the samples increased with the increasing percent of the drug and with release time. The kinetic profiles were accelerated with the loading ratio and with the presence of flow. Young′s modulus and ultimate stress were not significantly influenced by the release time. A relevant relationship between the tensile properties and the viscoelastic behavior of the samples was developed. Our results have implications for optimizing the performance of drug coatings for stents.

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