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Effect of arteriolar distensibility on the lateral migration of liquid-filled microparticles flowing in a human arteriole

Article dans une revue avec comité de lecture
Auteur
ccEL JIRARI, PhD, Dr Imane
ccEL BAROUDI, Adil
211916 Laboratoire Angevin de Mécanique, Procédés et InnovAtion [LAMPA]
ccAMMAR, Amine
211916 Laboratoire Angevin de Mécanique, Procédés et InnovAtion [LAMPA]

URI
http://hdl.handle.net/10985/23162
DOI
10.1142/S0219519421500627
Date
2021-10-15
Journal
Journal of Mechanics in Medicine and Biology

Résumé

A promising advance of bioengineering consists in the development of micro-nanoparticles as drug delivery vehicles injected intravenously or intraarterialy for targeted treatment. Pro cient functioning of drug carries is conditioned by a reliable prediction of pharma- cokinetics in human as well as their dynamical behavior once injected in blood stream. In this study we aim to provide a reliable numerical prediction of dynamical behavior of microparticles in human arteriole focusing on the crucial mechanism of lateral migration. The dynamical response of the microparticle upon blood flow and arteriolar distensibility is investigated by varying main controlling parameters: viscosity ratio, con nement and capillary number. The influence of the hyperelastic arteriolar wall is highlighted through comparison with an in nitely rigid arteriolar wall. The hydrodynamic interaction in a microparticle train is examined. Fluid-structure interaction is solved by the Arbitrary Lagrangian Eulerian method using the COMSOL Multiphysics software.

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  • Laboratoire Angevin de Mécanique, Procédés et InnovAtion (LAMPA)

Documents liés

Visualiser des documents liés par titre, auteur, créateur et sujet.

  • Numerical investigation of the dynamical behavior of a fluid-filled microparticle suspended in human arteriole 
    Article dans une revue avec comité de lecture
    ccEL JIRARI, PhD, Dr Imane; ccEL BAROUDI, Adil; ccAMMAR, Amine (ASME, 2021-05-01)
    The study of artificial microparticles (capsules and vesicles) has gained a growing interest with the emergence of bioengineering. One of their promoting applications is their use as therapeutic vectors for drug delivery, ...
  • Three-dimensional investigation of the stokes eigenmodes in hollow circular cylinder 
    Article dans une revue avec comité de lecture
    RAZAFIMAHERY, Fulgence; ccEL BAROUDI, Adil (Hindawi Publishing Corporation, 2013)
    This paper studies the influence of boundary conditions on a fluid medium of finite depth.We determine the frequencies and the modal shapes of the fluid.The fluid is assumed to be incompressible and viscous. A potential ...
  • Theoretical and numerical investigations of frequency analysis of two circular cylinders oscillating in a incompressible viscous fluid 
    Article dans une revue avec comité de lecture
    RAZAFIMAHERY, Fulgence; ccEL BAROUDI, Adil (World Scientific Publishing, 2014)
    A potential flow is presented in this paper for the analysis of the fluid-structure interaction systems including, but not limited to, the idealized human head. The model considers a cerebro-spinal fluid (CSF) medium ...
  • Torsional Vibrations of Fluid-Filled Multilayered Transversely Isotropic Finite Circular Cylinder 
    Article dans une revue avec comité de lecture
    ABASSI, Wafik; RAZAFIMAHERY, Fulgence; ccEL BAROUDI, Adil (World Scientific Publishing, 2016)
    An analytical and numerical study for the torsional vibrations of viscous fluid-filled three-layer transversely isotropic cylinder is presented in this paper. The equations of motion of solid and fluid are respectively ...
  • Analytical approach for predicting vibration characteristics of an embedded elastic sphere in complex fluid 
    Article dans une revue avec comité de lecture
    ccYANG, Xi; ccEL BAROUDI, Adil; ccLE POMMELLEC, Jean Yves (Springer, 2020-02-11)
    Vibration characteristics of elastic nanostructures embedded in fluid medium have been used for biological and mechanical sensing, and also to investigate the materials mechanical properties. The fluid medium surrounding ...

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