Effect of surfactant in an airway closure model
Article dans une revue avec comité de lecture
A model of the bronchioles lined by the airway surface liquid is employed to investigate the Plateau-Rayleigh instability that can lead to the occlusion of the airways. This physiologically relevant phenomenon is normally occurring in distal airways, i.e., in the bronchioles from the seventh generation on. Special attention is paid to the effect of surfactant dispersed in the liquid phase and along the liquid-gas interface. A single-layer Newtonian film is simulated in a rigid capillary pipe in order to isolate the impact of the surfactant and unravel their complex dynamics coupled with the multiphase liquid-gas dynamics. Apart from the primary instability leading to airway closure, we focus on the postcoalescence wall stresses and stress gradients produced by the bifrontal plug growth. With our model, we demonstrate that increasing the surfactant concentration and their strength, the airway closure slows and the wall stresses are reduced up to 20%. Within the physiological application intended for our model, we study the stability of the multiphase system. We predict the generation at which airway closure will occur depending on the liquid lining thickness and the initial surfactant concentration.
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Article dans une revue avec comité de lectureROMANÒ, Francesco; FUJIOKA, H.; MURADOGLU, M.; GROTBERG, J. B. (American Physical Society, 2019)The closure of a human lung airway is modeled as an instability of a two-phase flow in a pipe coated internally with a Newtonian liquid. For a thick enough coating, the Plateau-Rayleigh instability creates a liquid plug ...
Effects of elastoviscoplastic properties of mucus on airway closure in healthy and pathological conditions Article dans une revue avec comité de lectureERKEN, O.; FAZLA, B.; MURADOGLU, M.; IZBASSAROV, D.; ROMANO, Francesco; GROTBERG, J. B. (American Physical Society (APS), 2023-05)Airway mucus is a complex material with both viscoelastic and viscoplastic properties that vary with healthy and pathological conditions of the lung. In this study, the effects of these conditions on airway closure are ...
Article dans une revue avec comité de lectureERKEN, O.; ROMANO, Francesco; GROTBERG, J.B.; MURADOGLU, M. (Cambridge University Press (CUP), 2022-01)Capillary instability of a two-layer liquid film lining a rigid tube is studied computationally as a model for liquid plug formation and closure of human airways. The two-layer liquid consists of a serous layer, also called ...
Article dans une revue avec comité de lectureBAHRANI, S. Amir; HAMIDOUCHE, Souria; MOAZZEN, Masoud; SECK, Khady; DUC, Caroline; MURADOGLU, Metin; GROTBERG, James B.; ROMANO, Francesco (Elsevier BV, 2022-02)The propagation and rupture of mucus plugs in human lungs is investigated experimentally by injecting synthetic mucus in a pre-wetted capillary tube. The rheology of our test liquid is thoroughly characterized, and four ...
Article dans une revue avec comité de lectureROMANO, Francesco; MURADOGLU, M.; FUJIOKA, H.; GROTBERG, J.B. (Cambridge University Press (CUP), 2021-02)Abstract