Propagation and rupture of elastoviscoplastic liquid plugs in airway reopening model
Article dans une revue avec comité de lecture
Auteur
Date
2022-02Journal
Journal of Non-Newtonian Fluid MechanicsRésumé
The propagation and rupture of mucus plugs in human lungs is investigated experimentally by injecting synthetic mucus in a pre-wetted capillary tube. The rheology of our test liquid is thoroughly characterized, and four samples of synthetic mucus are considered in order to reproduce elastoviscoplastic regimes of physiological interest for airway reopening. Our experiments demonstrate the significant impact of the viscoplasticity and viscoelasticity of mucus. In support to our experiments, we propose a one-dimensional reduced-order model that takes into account capillarity, and elastoviscoplasticity. Our model manages to capture the cross-section averaged dynamics of the liquid plug and is used to elucidate and interpret the experimental evidence. Relying on it, we show that the liquid film thickening due to non-Newtonian effects favors plug rupture, whereas the increase of the effective viscosity due to higher yield stresses hinders plug rupture. As a result of such two effects, increasing the polymeric concentration in the mucus phase leads to a net increase of the rupture time and traveling length. Hence, non-Newtonian effects hinder airway reopening.
Fichier(s) constituant cette publication
Cette publication figure dans le(s) laboratoire(s) suivant(s)
Documents liés
Visualiser des documents liés par titre, auteur, créateur et sujet.
-
Article dans une revue avec comité de lectureEmploying the moving particles' semi-implicit (MPS) method, this study presents a numerical framework for solving the Navier–Stokes equations for the propagation and the split of a liquid plug through a three-dimensional ...
-
Article dans une revue avec comité de lectureCHARLES, Antoine; ROMANO, Francesco; RIBEIRO, Thierry; AZIMI, Sam; ROCHER, Vincent; BAUDEZ, Jean-Christophe; BAHRANI, S. Amir (AIP Publishing, 2022-11)We investigate the laminar-to-turbulent transition for non-Newtonian Herschel–Bulkley fluids that exhibit either a shear-thinning or shear-thickening behavior. The reduced-order model developed in this study also includes ...
-
Article dans une revue avec comité de lectureA simplified mono-dimensional model for investigating the transition to turbulence in nonisothermal and non-Newtonian pipe flows is proposed. The flow stability is analyzed within the framework of such a model, showing ...
-
Article dans une revue avec comité de lectureROMANÒ, Francesco; FUJIOKA, H.; MURADOGLU, M.; GROTBERG, J. B. (American Physical Society, 2019)The closure of a human lung airway is modeled as an instability of a two-phase flow in a pipe coated internally with a Newtonian liquid. For a thick enough coating, the Plateau-Rayleigh instability creates a liquid plug ...