Quantitative Ultrasound of Cortical Bone in the Femoral Neck Predicts Femur Strength: Results of a Pilot Study
TypeArticles dans des revues avec comité de lecture
A significant risk of femoral neck (FN) fracture exists for men and women with an areal bone mineral density (aBMD) higher than the osteoporotic range, as measured with dual-energy X-ray absorptiometry (DXA). Separately measuring the cortical and trabecular FN compartments and combining the results would likely be a critical aspect of enhancing the diagnostic capabilities of a new technique. Because the cortical shell determines a large part of FN strength a novel quantitative ultrasound (QUS) technique that probes the FN cortical compartment was implemented, aimed at testing the sensitivity of the method to variations of FN cortical properties and FN strength. Nine femurs (women, mean age 83 years) were subjected to QUS to measure the through transmission time-of-flight (TOF) at the FN and mechanical tests to assess strength. Quantitative computed tomography (QCT) scans were performed to enable analysis of the dependence of TOF on bone parameters. DXA was also performed for reference. An ultrasound wave propagating circumferentially in the cortical shell, which TOF was not influenced by the properties of the trabecular compartment Q3, was measured in all specimens. Averaged TOF for nine FN measurement positions/orientations was significantly correlated to strength (R² = 0.79) and FN cortical QCT variables: total BMD (R² = 0.54); regional BMD in the inferoanterior (R² = 0.90) and superoanterior (R² = 0.57) quadrants; and moment of inertia (R² = 0.71). The results of this study demonstrate that QUS can perform a targeted measurement of the FN cortical compartment. Because the method involves mechanical guided waves, the QUS variable is related to the geometric and material properties of the cortical shell (cortical thickness, tissue elasticity, and porosity). This work opens the way to a multimodal QUS assessment of the proximal femur, combining our approach targeting the cortical shell with the existing modality sensitive to the trabecular compartment. In vivo feasibility of our approach has to be confirmed with experimental data in patients.
Files in this item
Showing items related by title, author, creator and subject.
Quantification of nonlinear elasticity for the valuation of submillimeter crack length in cortical bone HAUPERT, Sylvain; GUERARD, Sandra; MITTON, David; PEYRIN, Françoise; LAUGIER, Pascal (elsevier, 2015)The objective of this study was to investig ate the sensitivity of the nonlinear elastic properties of cortical bon e to the presence of a single submillime tric crac k. Nonli near elasticity was measured by nonlinear ...
Non Destructive Characterization of Cortical Bone MicroDamage by Nonlinear Resonant Ultrasound Spectroscopy HAUPERT, Sylvain; GUERARD, Sandra; PEYRIN, Françoise; MITTON, David; LAUGIER, Pascal (PlosOne, 2014)The objective of the study was to evaluate the ability of a nonlinear ultrasound technique, the so-called nonlinear resonant ultrasound spectroscopy (NRUS) technique, for detecting early microdamage accumulation in cortical ...
HAUPERT, Sylvain; GUERARD, Sandra; MITTON, David; PEYRIN, Françoise; LAUGIER, Pascal (Acoustical Society of America, 2012)Accumulation of bone microdamage is suspected to lead to severe impairment of mechanical properties with an increase in skeletal fragility and fracture risk. The objective of the study was to evaluate the sensitivity of ...
HAUPERT, Sylvain; LAUGIER, Pascal; GUERARD, Sandra; PEYRIN, Françoise; MITTON, David (IEEE, 2011)Accumulation of bone micro-damage is suspected to lead to severe impairment of mechanical properties with an increase in skeletal fragility and fracture risk. The objective of the study was to evaluate the potential of ...
GUERARD, Sandra; BAROU, Jean-Luc; PETIT, Julien; POISSON, Philippe (2014)This study examined whether the thermo-modeling process suits the thermal properties of the material constituting mouthformed mouthguards (MGs). Five mouth-formed MGs were compared: four commercially available MGs (SDITM, ...