Transport of species in a fibrous media during tissue growth

Abstract

Tissue engineering is of major importance in biomedical transplantation techniques. However, some questions subsist as for example the mass transport between each pahse (cell, fluide and solid). In a previous paper, a one-equation model was developed in order to model mass transport during in vitro tissue growth using the volume averaging method. Using a dimensionless form of the model and a convenient formulation of the effective dispersion tensor, a numerical resolution of the closure problem is proposed. Some results allowing to validate the numerical tool are presented. This validation is carried out using results available in the literature for 2-D unit cells and under-classes of our model (namely diffusion, diffusion/reaction and diffusion/advection problems). Finally, we provide some results for the complete model taking into account diffusion, reaction and advection in the three phase system.