A mechano-biological model of multi-tissue evolution in bone
TypeArticles dans des revues avec comité de lecture
Successfully simulating tissue evolution in bone is of significant importance in predicting various biological processes such as bone remodeling, fracture healing and osseointegration of implants. Each of these processes involves in different ways the permanent or transient formation of different tissue types, namely bone, cartilage and fibrous tissues. The tissue evolution in specific circumstances such as bone remodeling and fracturing healing is currently able to be modeled. Nevertheless, it remains challenging to predict which tissue types and organization can develop without any a priori assumptions. In particular, the role of mechano-biological coupling in this selective tissue evolution has not been clearly elucidated. In this work, a multi-tissue model has been created which simultaneously describes the evolution of bone, cartilage and fibrous tissues. The coupling of the biological and mechanical factors involved in tissue formation has been modeled by defining two different tissue states: an immature state corresponding to the early stages of tissue growth and representing cell clusters in a weakly neo-formed Extra Cellular Matrix (ECM), and a mature state corresponding to well-formed connective tissues. This has allowed for the cellular processes of migration, proliferation and apoptosis to be described simultaneously with the changing ECM properties through strain driven diffusion, growth, maturation and resorption terms. A series of finite element simulations were carried out on idealized cantilever bending geometries. Starting from a tissue composition replicating a mid-diaphysis section of a long bone, a steady-state tissue formation was reached over a statically loaded period of 10,000 h (60 weeks). The results demonstrated that bone formation occurred in regions which are optimally physiologically strained. In two additional 1000 h bending simulations both cartilaginous and fibrous tissues were shown to form under specific geometrical and loading cases and cartilage was shown to lead to the formation of bone in a beam replicating a fracture healing initial tissue distribution. This finding is encouraging in that it is corroborated by similar experimental observations of cartilage leading bone formation during the fracture healing process. The results of this work demonstrate that a multi-tissue mechano-biological model of tissue evolution has the potential for predictive analysis in the design and implementations of implants, describing fracture healing and bone remodeling processes.
Cette publication figure dans le(s) laboratoire(s) suivant(s)
Visualiser des documents liés par titre, auteur, créateur et sujet.
FRAME, Jamie C.; ROHAN, Pierre-Yves; CORTÉ, Laurent; ALLENA, Rachele (2018)Bone is a tissue with the remarkable capacity to adapt its structure to an optimized microstructural form depending on variations in the loading conditions. The remodeling process in bone produces distinct tis- sue ...
FRAME, Jamie C.; ROHAN, Pierre-Yves; CORTÉ, Laurent; ALLENA, Rachele (Elsevier, 2018)Bone is a tissue with the remarkable capacity to adapt its structure to an optimized microstructural form depending on variations in the loading conditions. The remodeling process in bone produces distinct tissue distributions ...
FRAME, Jamie C.; ROHAN, Pierre-Yves; CORTÉ, Laurent; ALLENA, Rachele (2017)Introduction Improper osseointegration of implants leading to poor mechanical anchoring or embrittlement of neighboring bone is a major concern in orthopedic surgery [1?]. This integration is known to depend on the complex ...
ROHAN, Pierre-Yves; PILLET, Hélène; SKALLI, Wafa; TRNKA, Julien; MANASSERO, Mathieu; VIATEAU, Véronique; CAROUX, Julien; CORTÉ, Laurent (2017)Introduction Rupture of the Anterior Cruciate Ligament (ACL) affects about 1 person over 3000 every year. The current standard care is based on ligament reconstruction by autograft from tendon tissues and is considered as ...
Microstructural characterization of annulus fibrosus by ultrasonography: a feasibility study with an in vivo and in vitro approach LANGLAIS, Tristan; DESPRAIRIES, Pierre; PIETTON, Raphaël; ROHAN, Pierre-Yves; DUBOUSSET, Jean; MEAKIN, Judith R.; WINLOVE, Peter C.; VIALLE, Raphaël; SKALLI, Wafa; VERGARI, Claudio (Springer, 2019)The main function of the intervertebral disc is biomechanical function, since it must resist repetitive high loadings, while giving the spine its flexibility and protecting the spinal cord from over-straining. It partially ...