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The discriminant role of mechanics during cell migration

Article dans une revue avec comité de lecture
Auteur
ALLENA, Rachele
466360 Institut de Biomecanique Humaine Georges Charpak

URI
http://hdl.handle.net/10985/17458
DOI
10.1016/j.jocit.2018.09.007
Date
2018
Journal
Journal of Cellular Immunotherapy

Résumé

Cell migration is a fundamental process involved in many mechanobiological phenomena such immune response, bone remodelling and tumorogenesis. During the last decades several numerical works have been proposed in the literature in order to unveil its main biological, chemical and mechanical principles. Here, I will show how a computational approach purely based on mechanics is able to reproduce cell migration in different configurations including migration under confinement, in presence of durotaxis and on flat substrates. A series of models will be presented each of which is based on three main ingredients: i) the active strains of the cell reproducing the cyclic protrusion-contraction movement of the cell (i.e. the polymerization and depolymerization processes), ii) the adhesion forces exerted by the cell on the surrounding and ii) the intra-synchronization between the active strains and the adhesion forces. I will show how mechanics play a critical role in determining the efficiency of the cell in terms of displacement, speed and forces.

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Nom:
IBHGC_JCT_2018_ALLENA_2.pdf
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Cette publication figure dans le(s) laboratoire(s) suivant(s)

  • Institut de Biomécanique Humaine Georges Charpak (IBHGC)

Documents liés

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  • On the mechanical interplay between intra- and inter-synchronization during collective cell migration : a numerical investigation 
    Article dans une revue avec comité de lecture
    ALLENA, Rachele; AUBRY, Denis; SHARPE, James (Springer Verlag, 2013)
    Collective cell migration is a fundamental process that takes place during several biological phenomena such as embryogenesis, immunity response, and tumorogenesis, but the mechanisms that regulate it are still unclear. ...
  • Diffusion model to describe osteogenesis within a porous titanium scaffold. 
    Article dans une revue avec comité de lecture
    SCHMITT, M.; ALLENA, Rachele; SCHOUMAN, T.; FRASCA, S.; COLLOMBET, J.M.; HOLY, X.; ccROUCH, Philippe (Taylor & Francis, 2015)
    In this study, we develop a two-dimensional finite element model, which is derived from an animal experiment and allows simulating osteogenesis within a porous titanium scaffold implanted in ewe's hemi-mandible during 12 ...
  • Cell Migration with Multiple Pseudopodia : Temporal and Spatial Sensing Models 
    Article dans une revue avec comité de lecture
    ALLENA, Rachele (Springer Verlag, 2013)
    Cell migration triggered by pseudopodia (or “false feet”) is the most used method of locomotion. A 3D finite element model of a cell migrating over a 2D substrate is proposed, with a particular focus on the mechanical ...
  • Healthy vs. osteoarthritic hips: A comparison of hip, pelvis and femoral parameters and relationships using the EOS® system 
    Article dans une revue avec comité de lecture
    BENDAYA, Samy; LAZENNEC, Jean-Yves; ANGLIN, Carolyn; ALLENA, Rachele; SELLAM, N.; THOUMIE, P.; ccSKALLI, Wafa (Elsevier, 2015)
    Osteoarthritis is a debilitating disease, for which the development path is unknown. Hip, pelvis and femoral morphological and positional parameters relate either to individual differences or to changes in the disease ...
  • Mechanical modelling of confined cell migration across constricted-curved micro-channels 
    Article dans une revue avec comité de lecture
    ALLENA, Rachele (Tech Science Press, 2014)
    Confined migration is a crucial phenomenon during embryogenesis, immune response and cancer. Here, a two-dimensional finite element model of a HeLa cell migrating across constricted-curved micro-channels is proposed. The ...

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