A mechanical model to investigate the role of the nucleus during confined cell migration
TypeArticles dans des revues avec comité de lecture
1. Introduction Cell migration in confinement plays a fundamental role in biological processes such as embryogenesis, immune response and tumorogenesis. Specifically, tumor cells continuously adapt their migratory behaviour to their environment. Therefore, it has become timely and essential for diagnostic purposes to quanti- tatively evaluate the cell deformability in confinement. Here, we propose a two-dimensional mechanical model to simulate the migration of a HeLa cell through a micro- channel. We will evaluate both the invasiveness of the cell and the mechanical forces exerted by the cell according to the surrounding microstructure.
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AUBRY, Denis; GUPTA, M.; LADOUX, B.; ALLENA, Rachele (IOPScience, 2015)Cell migration, a fundamental mechanobiological process, is highly sensitive to the biochemical and mechanical properties of the environment. Efficient cell migration is ensured by the intrinsic polarity of the cell, which ...
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On the mechanical interplay between intra- and inter-synchronization during collective cell migration : a numerical investigation ALLENA, Rachele; AUBRY, Denis; SHARPE, James (Springer, 2013)Collective cell migration is a fundamental process that takes place during several biological phenomena such as embryogenesis, immunity response, and tumorogenesis, but the mechanisms that regulate it are still unclear. ...
A Coupled Friction-Poroelasticity Model of Chimneying Shows that Confined Cells Can Mechanically Migrate Without Adhesions MONDESERT-DEVERAUX, Solenne; ALLENA, Rachele; AUBRY, Denis (Tech Science Press, 2018)Cell migration is the cornerstone of many biological phenomena such as cancer metastasis, immune response or organogenesis. Adhesion-based motility is the most renown and examined motility mode, but in an adhesion-free ...
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