A Cellular Potts energy-based approach to analyse the influence of the surface topography on single cell motility
TypeArticles dans des revues avec comité de lecture
cellular scale level, the cell behaviour, especially its migration, is affected by the specificities of the surface of the substrate, such as the stiffness of the surface and its roughness topography. The latter has been shown to have a great impact on various cell mechanisms, such as the cell adhesion, migration, or proliferation. In fact, the mere presence of micro roughness leads to an improvement of those mechanisms, with a better integration of the implants. However, the phenomena behind those improvements are still not clear. In this paper, we propose a three-dimensional (3D) model of a single cell migration using a Cellular Potts (CP) model to study the influence of the surface topography on cell motility. To do so, various configurations were tested, such as: (i) a substrate with a random roughness, (ii) a substrate with a rectangular groove pattern (parallel and perpendicular to the direction of motion), (ii) a substrate with a sinusoidal groove pattern. To evaluate the influence of the surface topography on cell motility, for each configuration, the cell speed and shape as well as the contact surface between the cell and the substrate have been quantified. Our numerical results demonstrate that, in agreement with the experimental observations of the literature, the substrate topography has an influence on the cell efficiency (i.e. cell speed), orientation and shape. Besides, we also show that the increase of the contact surface alone in presence of roughness is not enough to explain the improvement of cell migration on the various rough surfaces. Finally, we highlight the importance of the roughness dimension on cell motility. This could be a critical aspect to consider for further analyses and applications, such as surface treatments for medical applications.
Files in this item
Showing items related by title, author, creator and subject.
Topography and wettability characterization of surfaces manufactured by SLM and treated by chemical etching THENARD, Thomas; ALLENA, Rachele; CATAPANO, Anita; MESNARD, Michel; SAINTIER, Nicolas; MOHAMED, El May (Taylor & Francis, 2020)Selective Laser Melting process represents an interesting opportunity in the biomedical field to fabricate customized implants. However, the surface roughness of components obtained through additive manufacturing is a major ...
A multi-scale two-level optimisation strategy integrating a global/local modelling approach for composite structures IZZI, Michele Iacopo; MONTEMURRO, Marco; CATAPANO, Anita; PAILHES, Jérôme (2020)In this work, a multi-scale optimisation strategy for the preliminary design of composite structures involving design requirements at different scales, is presented. Such a strategy, denoted as GL-MS2LOS, has been formulated ...
Multi-scale optimisation of thin-walled structures by considering a global/local modelling approach IZZI, Michele Iacopo; MONTEMURRO, Marco; CATAPANO, Anita; FANTERIA, Daniele; PAILHES, Jérôme (2020)In this work, a design strategy for optimising thin-walled structures based on a global-local finite element (FE) modelling approach is presented. The preliminary design of thin-walled structures can be stated in the form ...
CATAPANO, Anita; MONTEMURRO, Marco (A.J.M. Ferreira, 2017)Anisotropic materials, such as fibre-reinforced composite materials, are extensively used in many industrial fields thanks to their mechanical performances. The main characteristic of an anisotropic material is the dependency ...
On the effective integration of manufacturability constraints within the multi-scale methodology for designing variable angle-tow laminates MONTEMURRO, Marco; CATAPANO, Anita (Elsevier, 2017)In this work a multi-scale two-level (MS2L) optimisation strategy for optimising VAT composites is presented. In the framework of the MS2L methodology, the design problem is split and solved into two steps. At the first ...