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A Cellular Potts energy-based approach to analyse the influence of the surface topography on single cell motility

Article dans une revue avec comité de lecture
Author
THENARD, Thomas
1001017 Institut de Biomécanique Humaine Georges Charpak [IBHGC]
CATAPANO, Anita
1002421 Institut de Mécanique et d'Ingénierie [I2M]
MESNARD, Michel
1002421 Institut de Mécanique et d'Ingénierie [I2M]
ALLENA, Rachele
1001017 Institut de Biomécanique Humaine Georges Charpak [IBHGC]

URI
http://hdl.handle.net/10985/19921
DOI
10.1016/j.jtbi.2020.110487
Date
2021
Journal
Journal of Theoretical Biology

Abstract

cellular scale level, the cell behaviour, especially its migration, is affected by the specificities of the surface of the substrate, such as the stiffness of the surface and its roughness topography. The latter has been shown to have a great impact on various cell mechanisms, such as the cell adhesion, migration, or proliferation. In fact, the mere presence of micro roughness leads to an improvement of those mechanisms, with a better integration of the implants. However, the phenomena behind those improvements are still not clear. In this paper, we propose a three-dimensional (3D) model of a single cell migration using a Cellular Potts (CP) model to study the influence of the surface topography on cell motility. To do so, various configurations were tested, such as: (i) a substrate with a random roughness, (ii) a substrate with a rectangular groove pattern (parallel and perpendicular to the direction of motion), (ii) a substrate with a sinusoidal groove pattern. To evaluate the influence of the surface topography on cell motility, for each configuration, the cell speed and shape as well as the contact surface between the cell and the substrate have been quantified. Our numerical results demonstrate that, in agreement with the experimental observations of the literature, the substrate topography has an influence on the cell efficiency (i.e. cell speed), orientation and shape. Besides, we also show that the increase of the contact surface alone in presence of roughness is not enough to explain the improvement of cell migration on the various rough surfaces. Finally, we highlight the importance of the roughness dimension on cell motility. This could be a critical aspect to consider for further analyses and applications, such as surface treatments for medical applications.

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  • Institut de Biomécanique Humaine Georges Charpak (IBHGC)
  • Institut de Mécanique et d’Ingénierie de Bordeaux (I2M)

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